Hunting for variants requires a concerted effort. South Africa and the UK were the first big countries to implement nationwide genomic surveillance efforts for SARS-CoV-2 as early as April 2020. Since early in the COVID pandemic, the Network for Genomics Surveillance in South Africa has been monitoring changes in SARS-CoV-2. This was a valuable tool to understand better how the virus spread. In late 2020, the network detected a new virus lineage, 501Y. V2, which later became known as the beta variant. Now a new SARS-CoV-2 variant has been identified – B.1.1.529. The World Health Organisation has declared it a variant of concern, and assigned it the name Omicron . To help us understand more, The Conversation Africa’s Ozayr Patel asked scientists to share what they know. What’s the science behind the search? Hunting for variants requires a concerted effort. South Africa and the UK were the first big countries to implement nationwide genomic surveillance efforts for SARS...